Rapid Diagnosis and Biomedical Research

Providing a clinically supported service for the rapid diagnosis and management of infectious and genetic disease.

2023

Diagnosis of childhood febrile illness using a multi-class blood RNA molecular signature

Dominic Habgood-Coote 1, Clare Wilson 1, Chisato Shimizu 2, Anouk M Barendregt 3, Ria Philipsen 4, Rachel Galassini 1, Irene Rivero Calle 5, Lesley Workman 6, Philipp K A Agyeman 7, Gerben Ferwerda 4, Suzanne T Anderson 8, J Merlijn van den Berg 3, Marieke Emonts 9, Enitan D Carrol 10, Colin G Fink 11, Ronald de Groot 4, Martin L Hibberd 12, John Kanegaye 2, Mark P Nicol 13, Stéphane Paulus 14, Andrew J Pollard 15, Antonio Salas 16, Fatou Secka 8, Luregn J Schlapbach 17, Adriana H Tremoulet 2, Michael Walther 8, Werner Zenz 18

Med. 2023 Sep 8;4(9):635-654.e5

A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children (PERFORM): a multi-cohort machine learning study

Heather R Jackson*, Judith Zandstra*, Stephanie Menikou, Melissa Shea Hamilton, Andrew J McArdle, Roman Fischer, Adam M Thorne, Honglei Huang, Michael W Tanck, Machiel H Jansen, Tisham De, Philipp K A Agyeman, Ulrich Von Both, Enitan D Carrol, Marieke Emonts, Irini Eleftheriou, Michiel Van der Flier, Colin Fink, Jolein Gloerich, Ronald De Groot, Henriette A Moll, Marko Pokorn, Andrew J Pollard, Luregn J Schlapbach, Maria N Tsolia, Effua Usuf, Victoria J Wright, Shunmay Yeung, Dace Zavadska, Werner Zenz, Lachlan J M Coin, Climent Casals-Pascual, Aubrey J Cunnington, Federico Martinon-Torres, Jethro A Herberg, Marien I de Jonge†, Michael Levin†, Taco W Kuijpers†, Myrsini Kaforou†, on behalf of the PERFORM consortium‡

Lancet Digital Health: 2023, Vol 5: 11 pp e774–785

2022

Circadian rhythms in the plant host influence rhythmicity of rhizosphere microbiota

Amy Newman, Emma Picot, Sian Davies, Sally Hilton, Isabelle A. Carré and Gary D. Bending

BMC Biol 20, 235 (2022)

Diagnostic accuracy of multiplex respiratory pathogen panels for influenza or respiratory syncytial virus infections: systematic review and meta-analysis

Sophie Jullien, Felicity Fitzgerald, Suzanne Keddie, Oliver Baerenbold, Quique Bassat, John Bradley, Jane Falconer, Colin Fink, Ruth Keogh, Heidi Hopkins and Marie Voice

BMC Infectious Diseases (2022) 22:785

Variation in CFHR3 determines susceptibility to meningococcal disease by controlling factor H concentrations

Vikrant Kumar, Richard B. Pouw, Matias I. Autio, Manfred G. Sagmeister, Zai Yang Phua, Lisa Borghini, Victoria J. Wright, Clive Hoggart, Bangfen Pan, Antson Kiat Yee Tan, Alexander Binder, Mieke C. Brouwer, Ellie Pinnock, Ronald De Groot, Jan Hazelzet, Marieke Emonts, Michiel Van Der Flier, Karl Reiter, Markus M. Nöthen, Per Hoffmann, EUCLIDS consortium, Luregn J. Schlapbach, Evangelos Bellos, Suzanne Anderson, Fatou Secka, Federico Martinón-Torres, Antonio Salas, Colin Fink, Enitan D. Carrol, Andrew J. Pollard, Lachlan J. Coin, Werner Zenz, Diana Wouters, Lay Teng Ang, Martin L. Hibberd, Michael Levin, Taco W. Kuijpers, and Sonia Davila

American Journal of Human Genetics. 2022 Sep 1; 109(9): 1680–1691
ISSN 0002-9297

Low levels of factor H family proteins during meningococcal disease indicate systemic processes rather than specific depletion by Neisseria meningitidis

van Beek, Anna E, Pouw, Richard B, Wright, Victoria J, Sallah, Neneh, Inwald, David, Hoggart, Clive, Brouwer, Mieke C, Galassini, Rachel, Thomas, John, Calvo-Bado, Leo A, Fink, Colin, Jongerius, Ilse, Hibberd, Martin, Wouters, Diana, Levin, Michael and Kuijpers, Taco W on behalf of the EUCLIDS Consortium

Frontiers in Immunology, 13-2022
ISSN 1664-3224

First report of black rot caused by Xanthomonas nasturtii onwatercress in Spain and Portugal

D. M. Lascelles1,2 M. R. Roberts2 L. Cruz3 J. Cruz3 D. J. Studholme4 J. Harrison4 S. F. Greer5 M. Grant5 J. M. Holden6 B. Carter7 A. Bryning7 S. Carroll7 A. Aspin7 J. G. Vicente5,7

New Dis Rep. 2022;46:e12134. DOI: https://doi.org/10.1002/ndr2.12134

The temporal pattern and lifestyle associations of respiratory virus infection in a cohort study spanning the first two years of life

Powell E, Sumner E, Shaw AG, Calvez R, Fink CG, Kroll JS

BMC Pediatr. 2022 Mar 31;22(1):166 DOI: doi: 10.1186/s12887-022-03215-3. PMID: 35361147

Comparing lateral flow testing with a rapid RT-PCR method for SARS-CoV-2 detection in the United Kingdom – A retrospective diagnostic accuracy study

Taylor A, Calvez R, Atkins M, Fink CG

Health Sci Rep. 2022;5:e811 DOI: doi:10.1002/hsr2.811

2021

Loss of Factor H family proteins associates with meningococcal disease severity

Anna E. van, Richard B. Pouw, Victoria J. Wright, Neneh Sallah, David Inwald, Clive Hoggart, Mieke C. Brouwer, Rachel Galassini, John Thomas, Leo Calvo-Bado, Colin Fink, Ilse Jongerius, Martin Hibberd, Diana Wouters, Michael Levin, Taco W. Kuijpers

2021

High-throughput sequencing reveals dietary segregation in Malaysian babblers

Mohammad Saiful Mansor, Fasihah Zarifah Rozali, Sian Davies, Shukor Md. Nor, Rosli Ramli

Current Zoology, 2021

Mechanisms Involved in the Active Secretion of CTX-M-15b-Lactamase by Pathogenic Escherichia coli ST131

Severine Rangama,a Ian D. E. A. Lidbury, a,b Jennifer M. Holden,a,c Chiara Borsetto, a Andrew R. J. Murphy, a Peter M. Hawkey,d Elizabeth M. H. Wellington

Rangama et al. 2021 Volume 65 Issue 10 e00663-21 Antimicrobial Agents and Chemotherapy

School of Life Sciences, University of Warwick, Coventry, United Kingdom
bDepartment of Animal and Plant Science, The University of Sheffield, Sheffield, United Kingdom
c Micropathology Ltd., University of Warwick Science Park, Coventry, United Kingdom
dInstitute of Microbiology and Infection, University of Birmingham, Edgbaston, United Kingdom