Causes of Fever in a Cohort of Nepali Children and the Potential Impact of Molecular Testing During a Dengue Fever Outbreak
Peter J. O’Reilly , MBBCh, DPhil,* Madhav C. Gautam, MSc,† Bhishma Pokhrel, MD,† Sonu Shrestha, MSc,* Meeru Gurung, MD, MPhil,† Sanjeev M. Bijukchhe, MBBS, MSc,† Elizabeth O’Mahony, MBChB, MRCPCH,* Catherine Davis, BSc,‡ Andrew Taylor, BSc, MSc, PhD,‡ Sarah Kelly, MSc,*§ Ruby Basi, BA,† Anushiya Kattel, MBBS,† Kushal Gautam, MBBS,† Shriya Bista, MBBS,† Roshan Jha, MBBS,† Ram Khadka, MBBS,† Saugat Bhandari, MBBS,† Puja Amatya, MD,† Ganesh Shah, MD,† Ira Shrestha, MD,† Michael Carter, MRCPCH, DPhil,¶ Shreekrishna Maharjan, MD,† Colin Fink, MB, ChB, PhD,‡ Michael Levin, PhD, FMedSci,∥ Aubrey J. Cunnington, BMBCh, PhD,∥ Andrew J. Pollard, PhD, FMedSci,*§ and Shrijana Shrestha, MBBS, MD,† on Behalf of the DIAMONDS Consortium
The Pediatric Infectious Disease Journal • 2026
Predicting trajectories of acute illness using RNA velocity of whole blood
Claire Dunican1,2, Clare Wilson1,2, Dominic Habgood-Coote1, Suzanna Paterson1, Mahdad Noursadeghi3, Raymond Moseki46, Cari StekTBC2, Robert Wilkinson1,47,48, Philipp KA Agyeman4, Coco Beudeker5, Giske Biesbroek23, Ulrich von Both6,7, Karen Brengel-Pesce8-10, Enitan D Carrol11,12, Lachlan CoinTBC3, Giselle D’Souza1, Tisham De1, Marieke Emonts13-15, Katy Fidler16, Colin G. Fink17, Michiel van der Flier5,18-20, Ioanna Georgaki21, Laura Kolberg6, Mojca Kolnik22, Taco Kuijpers23-25, Federico Martinón-Torres26,27, Marine Mommert8,9, Samuel Nichols1, Stephane Paulus28,29, Marko Pokorn22,30,31, Andrew J Pollard28,29, Irene Rivero-Calle26,27, Aleksandra Rudzate32,33, Luregn J Schlapbach34,35, Nina Schweintzger36, Ching-Fen Shen37, Shrijana Shrestha38, Chantal Tan39, Maria Tsolia21, Effua Usuf40, Fabian van der Velden13-15, Clementien L. Vermont39,41, Marie Voice17, Shunmay Yeung42,43, Dace Zavadska32,33, Werner Zenz36, Victoria Wright1,2, Mike Levin1,2, Jethro Herberg1,2, on behalf of the PERFORM Consortium*, Rachel PJ Lai1, Graeme Meintjes44, Christopher Chiu1, Mauricio Barahona45, Myrsini Kaforou1,2, Aubrey J Cunnington1,2,†.
1. Department of Infectious Disease, Imperial College referred to Nature Communications – April 2025
A diagnostic host-specific transcriptome response for Mycoplasma pneumoniae pneumonia to guide pediatric patient treatment
Antonio Salas, Sandra Viz-Lasheras, Alberto Gómez-Carballa, Xabier Bello, Irene Rivero Calle, Ana Dacosta-Urbieta, Myrsini Kaforou, Dominic Habgood-Coote, Marieke Emonts, Jethro Herberg, Victoria Wright, Enitan Carrol, Stephane Paulus, Werner Zenz, Daniela Kohlfürst, Nina Schweintzger, Ronald de Groot, Luregn Schlapbach, Philipp Agyeman, Andrew Pollard, Colin Fink, Taco Kuijpers, Suzanne Anderson, Clementien Vermont, Michael Levin#, Federico Martinon-Torres, Michiel Van der Flier, Aubrey Cunnington, Ulrich von Both, Dace Zavadska, Marko Pokorn, María Tsolia, and Henriette Moll
[Paper #NCOMMS-24-45508B]
Article reference: ISCI_ISCIENCE-D-24-02117 Article title: A 5-transcript signature for discriminating viral and bacterial etiology in pediatric pneumonia
Immunity to Streptococcus pyogenes and Common Respiratory Viruses at Age 0 to 4 Years After COVID-19 Restrictions
Kitt Dokal, MBBS; Samuel Channon-Wells, MMath; Catherine Davis, BSc; Diego Estrada-Rivadeneyra, PhD; Kristin K. Huse, PhD; Amelia Lias, MRes; Shea Hamilton, PhD; Rebecca L. Guy, MSc; Theresa Lamagni, PhD; Sam Nichols, PhD; Andrew Taylor, PhD; Philipp K. A. Agyeman, MD; Amutha Anpananthar, MSc; Romain Basmaci, PhD; Enitan D. Carrol, MD; Michael J. Carter, DPhil; Tisham De, PhD; Marien I. de Jonge, PhD; Marieke Emonts, PhD; Leire Estramiana Elorrieta, MSc; Katy Fidler, PhD; Mojca Kolnik, MD; Taco W. Kuijpers, PhD; Federico Martinon-Torres, PhD; Henriette Moll, PhD; Marine Mommert-Tripon, PhD; Samira Neshat, MD; Maggie Nyirenda-Nyang’wa, PhD; Sean O’Riordan, PhD; Daniel R. Owens, PhD; Nazima Pathan, PhD; Stephane Paulus, MD; Mark J. Peters, PhD; Marko Pokorn, PhD; Andrew J. Pollard, PhD; Irene Rivero-Calle, PhD; Pablo Rojo, PhD; Lorenza Romani, MD; Prita Rughani, MBBS, BSc; Luregn J. Schlapbach, PhD; Nina A. Schweintzger, PhD; Ching-Fen Shen, MD; Artur Sulik, PhD; Maria Tsolia, PhD; Effua Usuf, PhD; Michiel van der Flier, PhD; Clementien Vermont, PhD; Ulrich von Both, MD; Paul Wellman, MRes; Victoria J. Wright, PhD; Shunmay Yeung, PhD; Dace Zavadska, PhD; Aubrey J. Cunnington, PhD; Colin Fink, PhD; Jethro Herberg, PhD; Myrsini Kaforou, PhD; Shiranee Sriskandan, PhD; Michael Levin, PhD; Tom Parks, MD; for the PERFORM and DIAMONDS consortiums
JAMA Network Open. 2025;8(10):e2537808. doi:10.1001/jamanetworkopen.2025.37808
External validation of a multivariable prediction model for identification of pneumonia and other serious bacterial infections in febrile immunocompromised children
Martin AJ, Van Der Velden FJS, Von Both U, Tsolia MN, Zenz W, Sagmeister M, Vermont C, De Vries G, Kolberg L, Lim E, Pokorn M, Zavadska D, Martinon-Torres F, Rivero-Calle I, Hagedoorn NN, Usuf E, Schlapbach L, Kuijpers TW, Pollard AJ, Yeung S, Fink C, Voice M, Carrol E, Agyeman PKA, Khanijau A, Paulus S, De T, Herberg JA, Levin M, Van Der Flier M, De Groot R, Nijman R, Emonts M
Archives of Disease in Childhood: 2024 Vol: 109: 1 pp: 58-66
Plasma Protein Biomarkers Distinguish Multisystem Inflammatory Syndrome in Children From Other Pediatric Infectious and Inflammatory Diseases
Yeoh S, Estrada-Rivadeneyra D, Jackson H, Keren I, Galassini R, Cooray S, Shah P, Agyeman P, Basmaci R, Carrol E, Emonts M, Fink C, Kuijpers T, Martinon-Torres F, Mommert-Tripon M, Paulus S, Pokorn M, Rojo P, Romani L, Schlapbach L, Schweintzger N, Shen C-F, Tsolia M, Usuf E, van der Flier M, Vermont C, von Both U, Yeung S, Zavadska D, Coin L, Cunnington A, Herberg J, Levin M, Kaforou M, Hamilton S, PERFORM, DIAMONDS and UK KD Genetic Consortia close
2024 Pediatr Infect Dis J
Archives of Disease in Childhood: 2024 Vol: 109: 1 pp: 58-66
Novel finding of vaccine-derived rubella virus-associated granulomata in an adult patient post-allogeneic haematopoietic stem cell transplant
Emily Durity1,2 Jiexin Zheng3 Emilie Sanchez4 Matthew Donati5 Keith Perry6 Jade Derrick6 Andy Taylor7 Colin Fink7 Jennifer Holden7 Paul Grant8 Matt Byott9 William Rickaby10 Nathan Asher10 Stephen L. Walker1,11,12 Kirsty Thomson3 Chris Bunker3,13,14,15
Br J Haematol. 2024;00:1–4
1 Department of Dermatology, University College London Hospitals NHS Foundation Trust, London, UK 2 Department of Dermatology, Guy’s and St Thomas’ NHS Foundation Trust, London, UK 3 University College London Hospitals NHS Foundation Trust, London, UK 4 Department of Virology, Infection Division, University College London Hospitals NHS Foundation Trust, London, UK 5 Specialised Microbiology and Laboratories, South West Regional Laboratory, UK Health Security Agency, Bristol, UK 6 Virus Reference Department, United Kingdom Health Security Agency, London, UK 7 Micropathology Ltd, Coventry, UK 8 Health Services Laboratories, London, UK
Genomic investigations of unexplained acute hepatitis in children
Sofia Morfopoulou, Sarah Buddle, Oscar Enrique Torres Montaguth, Nathaniel Storey, Laura Atkinson, José Afonso Guerra-Assunção, Sunando Roy, Alexander Lennon, Jack C D Lee, Rachel Williams, Charlotte A Williams, Helena Tutill, Nadua Bayzid, Luz Marina Martin Bernal, Catherine Moore, Kate Templeton, Claire Neill, Matt Holden, Priyen Shah, Samantha Coorey, Marie Voice, Michael Steele, Colin Fink, Thomas E Whittaker, Giorgia Santilli, Paul Gissen, Simon N Waddington, Juan Diaz, Thomas S Jacques, Chayarani Kelgeri, Rachel Brown, DIAMONDS and PERFORM consortia, James Hatcher, Surjo De, Glenn Anderson, Eileen Gallagher, Ruth Simmons, Conall Watson, Sema Mandal, Julien Andreani, Peter Simmonds, Maria Zambon, Meera Chand, Luis Campos, Joanne Martin, Emma Thomson, Michael Levin, Ines Ushiro-Lumb, Julianne R Brown, Judith Breuer
Nature volume 617, pages 564–573 (2023)
Febrile illness in high-risk children: a prospective, international observational study
Fabian J S van der Velden, Gabriella de Vries, Alexander Martin, Emma Lim, Ulrich von Both, Laura Kolberg, Enitan D Carrol, Aakash Khanijau, Jethro A Herberg, Tisham De, Rachel Galassini, Taco W Kuijpers, Federico Martinón-Torres, Irene Rivero-Calle, Clementien L Vermont, Nienke N Hagedoorn, Marko Pokorn, Andrew J Pollard, Luregn J Schlapbach, Maria Tsolia, Irini Elefhteriou, Shunmay Yeung, Dace Zavadska, Colin Fink, Marie Voice, Werner Zenz, Benno Kohlmaier, Philipp K A Agyeman, Effua Usuf, Fatou Secka, Ronald de Groot, Michael Levin, Michiel van der Flier, Marieke Emonts; PERFORM consortium
European Journal of Pediatrics, 2023 Feb;182(2):543-554
Diagnosis of childhood febrile illness using a multi-class blood RNA molecular signature
Dominic Habgood-Coote 1, Clare Wilson 1, Chisato Shimizu 2, Anouk M Barendregt 3, Ria Philipsen 4, Rachel Galassini 1, Irene Rivero Calle 5, Lesley Workman 6, Philipp K A Agyeman 7, Gerben Ferwerda 4, Suzanne T Anderson 8, J Merlijn van den Berg 3, Marieke Emonts 9, Enitan D Carrol 10, Colin G Fink 11, Ronald de Groot 4, Martin L Hibberd 12, John Kanegaye 2, Mark P Nicol 13, Stéphane Paulus 14, Andrew J Pollard 15, Antonio Salas 16, Fatou Secka 8, Luregn J Schlapbach 17, Adriana H Tremoulet 2, Michael Walther 8, Werner Zenz 18
Med. 2023 Sep 8;4(9):635-654.e5
A multi-platform approach to identify a blood-based host protein signature for distinguishing between bacterial and viral infections in febrile children (PERFORM): a multi-cohort machine learning study
Heather R Jackson*, Judith Zandstra*, Stephanie Menikou, Melissa Shea Hamilton, Andrew J McArdle, Roman Fischer, Adam M Thorne, Honglei Huang, Michael W Tanck, Machiel H Jansen, Tisham De, Philipp K A Agyeman, Ulrich Von Both, Enitan D Carrol, Marieke Emonts, Irini Eleftheriou, Michiel Van der Flier, Colin Fink, Jolein Gloerich, Ronald De Groot, Henriette A Moll, Marko Pokorn, Andrew J Pollard, Luregn J Schlapbach, Maria N Tsolia, Effua Usuf, Victoria J Wright, Shunmay Yeung, Dace Zavadska, Werner Zenz, Lachlan J M Coin, Climent Casals-Pascual, Aubrey J Cunnington, Federico Martinon-Torres, Jethro A Herberg, Marien I de Jonge†, Michael Levin†, Taco W Kuijpers†, Myrsini Kaforou†, on behalf of the PERFORM consortium‡
Lancet Digital Health: 2023, Vol 5: 11 pp e774–785
